Document Type
Article
Publication
BMJ Open
Year
2022
Citation Information
Govind Persad, Govind C. Persad, William F. Parker, and Srinivas Murthy, Dose Optimisation and Scarce Resource Allocation: Two Sides of the Same Coin, (2022), available at https://scholar.law.colorado.edu/faculty-articles/2037.
Abstract
Objective: A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.
Summary of key data: The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in health care systems –has been ignorant of scarcity and dose optimisation's ability to help address it.
Conclusions: Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values.